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It is possible to explain the role of mediators using an experimental model of autoimmune encephalitis: Protection against the experimental disease occurs after administration of a glutamate antagonist [10]

Hullstein, I., Sagredo, C

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Proc Natl Acad Sci U S A 103 : 72827287 Lpez M, Lage R, Saha AK, Prez-Tilve D, Vzquez MJ, Varela L, Sangiao-Alvarellos S, Tovar S, Raghay K, Rodrguez-Cuenca S, Deoliveira RM, Castaeda T, Datta R, Dong JZ, Culler M, Sleeman MW, Alvarez CV, Gallego R, Lelliott CJ, Carling D, Tschp MH, Diguez C, Vidal-Puig A 2008 Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin